Loss of the habenula neuromodulator Kisspeptin1 disrupts learning in larval zebrafish Short title: Habenula modulation and operant learning
نویسنده
چکیده
Department of Animal and Plant Sciences, Alfred Denny Building, University of Sheffield, Sheffield S10 2TN, UK; Institute for Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673; National Centre for Biological Sciences, GKVK Campus, Bellary Rd, Bengaluru, Karnataka 560065, India; Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921; NUS Graduate School for Integrative Sciences and Engineering, 28 Medical Drive Singapore 117456; Duke-NUS Graduate Medical School, 8 College Road, Singapore169857.
منابع مشابه
Loss of the Habenula Intrinsic Neuromodulator Kisspeptin1 Affects Learning in Larval Zebrafish
Learning how to actively avoid a predictable threat involves two steps: recognizing the cue that predicts upcoming punishment and learning a behavioral response that will lead to avoidance. In zebrafish, ventral habenula (vHb) neurons have been proposed to participate in both steps by encoding the expected aversiveness of a stimulus. vHb neurons increase their firing rate as expectation of puni...
متن کامل1 Loss of the habenula neuromodulator Kisspeptin 1 disrupts learning
Learning how to actively avoid a predictable aversive stimulus involves two steps: recognizing the cue that predicts upcoming punishment, and learning a behavioral response that will lead to avoidance. In zebrafish, ventral habenula (vHb) neurons have been proposed to participate in both steps by encoding the expected aversiveness of a stimulus. vHb neurons increase their firing rate as expecta...
متن کاملThe Right Dorsal Habenula Limits Attraction to an Odor in Zebrafish
BACKGROUND The habenula consists of an evolutionarily conserved set of nuclei that control neuromodulator release. In lower vertebrates, the dorsal habenula receives innervation from sensory regions, but the significance of this is unclear. Here, we address the role of the habenula in olfaction by imaging neural activity in larval zebrafish expressing GCaMP3 throughout the habenula and by carry...
متن کاملNeuronal connectivity between habenular glutamate‐kisspeptin1 co‐expressing neurons and the raphe 5‐HT system
The habenula, located on the dorsal thalamic surface, is an emotional and reward processing center. As in the mammalian brain, the zebrafish habenula is divided into dorsal (dHb) and ventral (vHb) subdivisions that project to the interpeduncular nucleus and median raphe (MR) respectively. Previously, we have shown that kisspeptin 1 (Kiss1) expressing in the vHb, regulates the serotonin (5-HT) s...
متن کاملThe Habenula Prevents Helpless Behavior in Larval Zebrafish
Animals quickly learn to avoid predictable danger. However, if pre-exposed to a strong stressor, they do not display avoidance even if this causes continued contact with painful stimuli [1, 2]. In rodents, lesioning the habenula, an epithalamic structure that regulates the monoaminergic system, has been reported to reduce avoidance deficits caused by inescapable shock [3]. This is consistent wi...
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تاریخ انتشار 2016